GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs12196860 | 1 | rs12190695 | chr6:55943429 | COL21A1 | chr6:55921389-56258892:- | -0.38 | -6.95 | 6.57E-12 | Psychosis (atypical) |
| BRCA | cis | rs12196860 | 1 | rs12190930 | chr6:55977027 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.84 | 1.31E-11 | Psychosis (atypical) |
| BRCA | cis | rs2274459 | 1 | rs12190954 | chr6:33746618 | IP6K3 | chr6:33689443-33714762:- | 0.25 | 4.41 | 1.13E-5 | Obesity (extreme) |
| BRCA | cis | rs12196860 | 1 | rs12191865 | chr6:56014006 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.89 | 9.79E-12 | Psychosis (atypical) |
| BRCA | cis | rs4947019 | 1 | rs12192279 | chr6:110055313 | AKD1 | chr6:109814059-110012415:- | 0.26 | 4.2 | 2.83E-5 | Hematological parameters |
| BRCA | cis | rs4947019 | 1 | rs12192279 | chr6:110055313 | ARMC2 | chr6:109169619-109295350:+ | 0.24 | 3.77 | 0.00017 | Hematological parameters |
| BRCA | cis | rs4947019 | 1 | rs12192279 | chr6:110055313 | FIG4 | chr6:110012424-110146634:+ | 0.26 | 3.74 | 0.000192 | Hematological parameters |
| BRCA | cis | rs4947019 | 1 | rs12192279 | chr6:110055313 | PPIL6 | chr6:109711419-109761990:- | 0.31 | 5.01 | 6.5E-7 | Hematological parameters |
| BRCA | cis | rs4947019 | 1 | rs12192279 | chr6:110055313 | ZBTB24 | chr6:109783719-109804440:- | 0.2 | 3.42 | 0.000652 | Hematological parameters |
| BRCA | cis | rs1577917 | 1 | rs12192992 | chr6:86609915 | SNHG5 | chr6:86386726-86388451:- | -0.6 | -18.71 | 8.84E-68 | Response to antipsychotic treatment |
| BRCA | cis | rs2274459 | 1 | rs12193658 | chr6:33705528 | IP6K3 | chr6:33689443-33714762:- | 0.25 | 4.35 | 1.52E-5 | Obesity (extreme) |
| BRCA | cis | rs12196860 | 1 | rs12193911 | chr6:55966889 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.81 | 1.58E-11 | Psychosis (atypical) |
| BRCA | cis | rs12196860 | 1 | rs12194192 | chr6:55954089 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.84 | 1.34E-11 | Psychosis (atypical) |
| BRCA | cis | rs12196860 | 1 | rs12194997 | chr6:55970434 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.77 | 2.07E-11 | Psychosis (atypical) |
| BRCA | cis | rs12196860 | 1 | rs12195340 | chr6:55967008 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.8 | 1.71E-11 | Psychosis (atypical) |